decellularization

Decellularization is a process used to remove cells from a piece of tissue or an organ, leaving behind the natural framework called the extracellular matrix. This matrix provides the structural support and important cues for cell growth and function. By removing the cells, which can cause immune reactions if transplanted directly, scientists create a scaffold that can be repopulated with new, patient-specific cells. This technique is valuable in regenerative medicine and tissue engineering, as it helps develop customized tissues and organs for transplantation, reducing rejection risks and improving integration within the body.