cytokine release syndrome (CRS)

Cytokine release syndrome (CRS) is an intense immune response triggered when the body’s immune cells release large amounts of signaling proteins called cytokines. This often happens during certain treatments like immunotherapy or infections. The excessive cytokines cause widespread inflammation, leading to symptoms such as fever, fatigue, and difficulty breathing. In severe cases, CRS can affect multiple organs and become life-threatening. It’s a hyperactive immune reaction that requires careful monitoring and management to prevent complications while allowing beneficial immune responses to target disease.