cyclic nucleotide phosphodiesterases (PDEs)

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate cell signaling by breaking down molecules called cyclic nucleotides (like cAMP and cGMP). These cyclic nucleotides act as messengers, transmitting signals within cells to control processes such as mood, blood flow, and immune response. PDEs ensure that these signals are temporary and properly controlled by degrading cyclic nucleotides when they're no longer needed. Different types of PDEs target specific cyclic nucleotides, making them crucial for maintaining cellular balance and offering targets for drugs that treat various conditions like depression, cardiovascular diseases, and erectile dysfunction.