cyclic nucleotide phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate important chemical messengers in the body called cyclic nucleotides (cAMP and cGMP). These messengers control processes such as heart rate, muscle contraction, and neural signaling. PDEs work by breaking down cAMP and cGMP, turning off their signals and helping the body respond appropriately to different stimuli. Different types of PDEs are found in various tissues, ensuring precise control of these signaling pathways. By modulating PDE activity, medications can influence processes like inflammation, blood flow, and cell growth.