Cullin-RING ligases

Cullin-RING ligases (CRLs) are a family of protein complexes that play a vital role in controlling protein levels within cells. They function as molecular machines that attach small tags called ubiquitin to specific proteins, marking them for destruction or altering their activity. This process is essential for maintaining cellular health, regulating processes like cell division, DNA repair, and signaling. CRLs are composed of a core scaffold protein called cullin, a RING finger protein, and other specific adaptors, working together to ensure proteins are properly regulated in response to the cell’s needs.