CSL (CBF1/Su(H)/LAG-1)

CSL (CBF1/Su(H)/LAG-1) is a family of transcription factors that are conserved across many organisms, including humans, animals, and fungi. They play a central role in the Notch signaling pathway, a communication system that controls cell growth, development, and differentiation. When a signal activates Notch, CSL proteins bind to specific DNA regions to turn genes on or off, guiding cell behavior. Without this pathway, proper development would be disrupted, leading to issues like cancer or developmental defects. In essence, CSL proteins are critical mediators that translate external signals into precise genetic responses.