Cryo-ESEM

Cryo-Environmental Scanning Electron Microscopy (Cryo-ESEM) combines advanced imaging with temperature control, allowing scientists to examine delicate, hydrated samples—like biological tissues or fluids—in their natural, frozen state. Unlike traditional microscopes that require samples to be dry, Cryo-ESEM maintains samples near freezing, preventing structure damage from dehydration or vacuum conditions. This technique provides high-resolution, detailed images of samples' surfaces and internal features while preserving their original hydration and morphology, enabling better understanding of biological processes and material structures in their native environment.