CQ (Chloroquine) Resistance

Chloroquine resistance occurs when malaria-causing parasites, mainly Plasmodium falciparum, develop the ability to survive despite treatment with chloroquine. This happens because the parasites mutate or change their genes, reducing the drug's effectiveness by altering how chloroquine is taken up or processed within the parasite. As a result, chloroquine no longer kills the parasites efficiently, making malaria harder to treat. This resistance is a significant challenge in controlling malaria globally and necessitates the use of alternative medications and strategies to combat the disease effectively.