Conformational coupling

Conformational coupling is a process where the shape or structure of one molecular component influences the shape of another nearby component, often within a larger complex like a cell receptor or enzyme. When one part changes shape—due to binding a signal or substrate—it transmits this change to another part, triggering a functional response such as activating a signaling pathway or opening a channel. This coordination ensures precise communication within biological systems, allowing cells to respond efficiently to their environment by translating structural shifts into specific actions.