Co-immunoprecipitation

Co-immunoprecipitation is a laboratory technique used to study interactions between proteins. It involves using an antibody that specifically binds to one target protein in a mixture, like a cell extract. When the antibody binds to its target, it also pulls along any other proteins attached to it—these are its interaction partners. By isolating this complex and analyzing it, researchers can identify proteins that work together within cells, helping to understand cellular functions and pathways. Essentially, co-immunoprecipitation reveals which proteins are physically associated in a biological context.