Class switch recombination

Class switch recombination (CSR) is a process in immune cells where the antibody-producing cell changes the type of antibody it makes, such as from IgM to IgG or IgA. This switch allows the immune system to produce antibodies that are more effective at fighting specific infections or reaching certain areas of the body. The process involves cutting and rejoining the DNA in the cell's genome, guided by signals from other immune cells, to change the antibody's constant region without altering its ability to recognize the pathogen. This enhances the immune response’s versatility and efficiency.