cisplatin resistance

Cisplatin resistance occurs when cancer cells adapt to survive despite treatment with the chemotherapy drug cisplatin. Normally, cisplatin damages the DNA inside cancer cells, leading to cell death. However, resistant cells may repair the DNA damage more effectively, pump the drug out more efficiently, or alter their biology to avoid the drug’s effects. These changes allow the cancer to continue growing despite treatment, making the therapy less effective. Understanding resistance helps researchers develop strategies to overcome it and improve treatment outcomes.