circulating donor-derived cell-free DNA (dd-cfDNA)

Circulating donor-derived cell-free DNA (dd-cfDNA) refers to small fragments of genetic material from a transplanted organ that are found in the recipient's blood. When the donor organ sustains some damage or rejection occurs, more of these DNA fragments are released into the bloodstream. Measuring dd-cfDNA helps doctors monitor the health of the transplanted organ non-invasively, providing early clues about potential rejection before symptoms appear. This method offers a valuable tool for ongoing transplant care, aiming to detect issues quickly and maintain the function of the transplanted organ.