Chk1 inhibitors

Chk1 inhibitors are drugs designed to block a protein called Chk1, which helps cells repair damage and pause their cycle during DNA stress. In cancer treatment, these inhibitors prevent cancer cells from repairing DNA damage effectively, making them more vulnerable to therapies like chemotherapy and radiation. By targeting Chk1, these drugs can increase cancer cell death while potentially sparing normal cells, especially when used with other treatments. Overall, Chk1 inhibitors are a promising approach to improve the effectiveness of cancer therapies by disrupting the cancer cells' ability to survive DNA damage.