CFTR Modulators

CFTR modulators are medications designed to improve the function of the CFTR protein, which is defective in cystic fibrosis. This protein helps regulate the movement of salt and water in and out of cells, essential for healthy mucus and lung function. In people with certain genetic mutations, CFTR doesn’t work properly, leading to thick mucus buildup. Modulators target these specific mutations to enhance the protein’s activity, helping to improve mucus clearance, reduce infections, and support overall lung health. They represent a personalized approach to treatment, addressing the underlying cause of cystic fibrosis rather than just managing symptoms.