centrosome amplification

Centrosome amplification occurs when cells have more than the normal two centrosomes, which are structures that organize cell division. This excess can lead to abnormal cell division, resulting in cells with unstable chromosomes and genetic errors. Such irregularities are often associated with cancer development, as they can promote genetic diversity within tumors, making cancer more aggressive and harder to treat. In essence, centrosome amplification disrupts normal cell division processes, contributing to disease progression and cellular instability.