cellular deconvolution

Cellular deconvolution is a method used to determine the different types and proportions of cells within a complex tissue sample, like a biopsy. When analyzing tissue, you often get a mixed signal because it contains many cell types working together. Deconvolution uses computer algorithms and reference data from known cell types to break down this mixed signal, identifying which cells are present and in what quantities. This helps researchers understand the tissue's composition and how it may change in diseases or in response to treatment, providing insights into the underlying biology without needing to physically separate each cell type.