CD44 Variant Isoforms

CD44 variant isoforms are different forms of a cell surface protein called CD44, which occur due to alternative splicing of its gene. These variants play roles in cell communication, adhesion, and migration, especially in immune responses and cancer progression. The standard form (CD44s) is common, but variant forms (such as CD44v) include extra segments that customize how cells interact with their environment. Understanding these isoforms helps researchers study their involvement in diseases like cancer, where certain variants may promote tumor growth and spread, making them important targets for diagnosis and therapy.