Castleman Disease

Castleman disease is a rare disorder characterized by abnormal growth of lymph node tissue, which can cause swelling and other symptoms depending on its type and location. It involves the overproduction of immune system proteins and cells, leading to enlarged lymph nodes and sometimes symptoms like fever, weight loss, or fatigue. There are two main types: unicentric, affecting a single lymph node, and multicentric, involving multiple nodes and more systemic symptoms. Treatment varies based on type and severity but may include medications, immunotherapy, or surgery. The exact cause remains unclear, but it involves abnormal immune system regulation.