Cardiolipin remodeling

Cardiolipin remodeling is a biological process where the cell fine-tunes the composition of cardiolipin, a special phospholipid found mainly in the inner mitochondrial membrane, which is vital for energy production. Initially, cardiolipin is produced with diverse fatty acids, but for optimal function, its fatty acids are selectively replaced or rearranged to achieve a specific composition. This remodeling ensures cardiolipin maintains mitochondrial efficiency and supports processes like respiration. Proper remodeling is crucial; defects can lead to mitochondrial dysfunction, contributing to diseases like heart failure and neurodegeneration.