BDNF Val66Met polymorphism

The BDNF Val66Met polymorphism is a genetic variation in the brain-derived neurotrophic factor (BDNF) gene, which influences brain health and function. Specifically, it involves a change where the amino acid valine (Val) is replaced by methionine (Met) at position 66. This variation affects how BDNF is stored and released, impacting processes like learning, memory, and mood regulation. People with the Met version may experience differences in cognitive flexibility and emotional resilience compared to those with the Val version, with potential implications for mental health and neuroplasticity.