BCR-ABL fusion gene

The BCR-ABL fusion gene is a genetic change often found in chronic myeloid leukemia (CML), a type of blood cancer. It occurs when parts of two genes—BCR and ABL—combine abnormally due to a chromosome mistake. This fusion creates a new protein that signals the blood cells to grow uncontrollably. This abnormal protein drives the cancer's development. Detecting the BCR-ABL gene helps diagnose CML and guides targeted treatments, like specific drugs that block this faulty protein to control the disease.