Array Comparative Genomic Hybridization (aCGH)

Array Comparative Genomic Hybridization (aCGH) is a laboratory technique used to detect genetic changes, such as missing or extra pieces of DNA, across a person’s genome. It compares a patient’s DNA to normal DNA by labeling both with different colors and hybridizing them to a microarray, which contains many known DNA segments. By analyzing the color ratios, scientists can identify chromosomal imbalances associated with various conditions, including genetic disorders and cancers. aCGH provides a detailed, genome-wide view of genetic alterations, aiding in accurate diagnosis and understanding of genetic diseases.