array comparative genomic hybridization

Array comparative genomic hybridization (aCGH) is a technique used to detect changes in DNA, such as deletions or duplications of genetic material, across the entire genome. It compares a person's DNA to a reference sample by labeling each with different colors and then hybridizing them onto a microarray chip. Differences in color signals reveal variations in gene copy numbers, helping identify genetic abnormalities associated with conditions like developmental disorders or cancer. aCGH provides a detailed, genome-wide view of genetic imbalances, aiding in precise diagnosis and understanding of genetic contributions to disease.