Array-Based Comparative Genomic Hybridization (aCGH)

Array-Based Comparative Genomic Hybridization (aCGH) is a laboratory technique used to detect changes in DNA copy number across the entire genome. By comparing a person’s DNA to a reference sample, the method identifies regions where there are extra copies (amplifications) or missing segments (deletions) of genetic material. This helps in diagnosing genetic disorders, cancers, and other conditions involving genetic abnormalities. The process involves labeling the DNA samples with different colors, hybridizing them to a microarray containing DNA probes, and analyzing the color signals to pinpoint genetic imbalances with high precision.