APPswe (Swedish mutation)

APPSwe (Swedish mutation) refers to a specific genetic change in the APP gene, which is involved in producing amyloid precursor protein linked to Alzheimer's disease. This mutation was first identified in Swedish families and enhances the production of amyloid-beta, a protein that accumulates in the brain and contributes to Alzheimer's pathology. Carriers of this mutation have a significantly increased risk of developing early-onset Alzheimer's, typically before age 65. Understanding APPswe helps researchers study how amyloid buildup triggers neurodegeneration, potentially guiding the development of targeted treatments for Alzheimer's disease.