APPROVe trial

The APPROVe trial was a clinical study that tested whether the drug rofecoxib (Vioxx) could prevent the return of colon polyps, which can lead to cancer. Conducted over several years, it compared patients taking the drug to those not taking it to see if it was safe and effective. The trial found that those on Vioxx had a higher risk of serious heart problems, leading to its widespread withdrawal from the market. The study helped demonstrate the importance of thorough testing for drug safety before approval and use.