APP mutation

APP mutation refers to changes in the gene that produces the amyloid precursor protein (APP), which is involved in brain cell communication. When these mutations occur, they can cause the APP to be processed abnormally, leading to the excessive buildup of amyloid-beta fragments. These fragments form sticky plaques in the brain, a hallmark of Alzheimer's disease. The mutation affects how the protein is made or cut, increasing the risk of developing Alzheimer’s by promoting plaque formation that damages brain cells and impairs memory and thinking.