APH-1 (Anterior pharynx-defective 1)

APH-1, or Anterior Pharynx-defective 1, is a protein involved in the Notch signaling pathway, which is crucial for cell communication and development. This pathway influences how cells grow, divide, and differentiate into different tissue types during embryonic development and in adult tissues. APH-1 is part of a complex that helps assemble and activate the gamma-secretase enzyme, which processes certain proteins like Notch receptors. Proper function of APH-1 ensures correct cell signaling, impacting tissue formation and maintenance. Disruptions in this process can lead to developmental abnormalities and have been linked to diseases such as cancer.