Antithyroid Peroxidase Antibodies

Antithyroid peroxidase (TPO) antibodies are immune system proteins that mistakenly attack the thyroid gland, specifically targeting the enzyme thyroperoxidase essential for hormone production. Their presence often indicates autoimmune thyroid conditions like Hashimoto’s thyroiditis or Graves’ disease. Elevated levels suggest the immune system is interfering with normal thyroid function, which can lead to symptoms such as fatigue, weight changes, or hormone imbalance. Testing for these antibodies helps healthcare providers diagnose, monitor, and manage thyroid-related disorders by understanding whether autoimmune activity is contributing to thyroid problems.