anti-Jo-1 antibody

Anti-Jo-1 antibodies are immune system proteins that mistakenly target a specific enzyme called histidyl-tRNA synthetase, which plays a role in protein production in cells. Their presence is often associated with certain autoimmune conditions, particularly polymyositis, an inflammatory muscle disease, and sometimes lung issues. These antibodies serve as markers helping doctors diagnose and understand these diseases. The immune system's attack on muscle tissue and other organs leads to symptoms like muscle weakness and fatigue. Detecting anti-Jo-1 antibodies helps guide treatment and provides insight into disease activity.