amphipathic helix

An amphipathic helix is a type of spiral-shaped segment within a protein that has both water-loving (hydrophilic) and water-fearing (hydrophobic) parts. This unique arrangement allows it to interact with different environments—its hydrophilic side faces water or the cell's exterior, while its hydrophobic side interacts with fats or the cell's interior membranes. This structure is essential for functions like anchoring proteins to membranes or helping them pass through cell barriers. Essentially, an amphipathic helix acts like a molecular compass, guiding proteins to their correct location within or outside the cell.