AIM-HIGH trial

The AIM-HIGH trial was a medical study that tested whether adding niacin (a form of vitamin B3) to cholesterol-lowering therapy would reduce heart attacks and strokes in people with cardiovascular disease. Participants already had good control of their LDL ("bad") cholesterol but still faced risk due to low HDL ("good") cholesterol and high triglycerides. The study found that although niacin raised HDL and lowered triglycerides, it did not significantly decrease the occurrence of heart-related events compared to standard treatment alone. The trial was stopped early because no additional benefit was observed.