Adams-Oliver syndrome

Adams-Oliver syndrome is a rare genetic condition characterized by two main features: A large or missing scalp skin (scalp defects) and abnormalities in the limbs, such as absent or underdeveloped fingers or toes. Some individuals may also have problems with the heart, blood vessels, or other organs. It results from mutations in specific genes that affect blood vessel formation and growth during early development. The severity varies among individuals. While it is lifelong, many people can lead active lives with appropriate medical care and interventions.