ACPA (Anti-Citrullinated Protein Antibodies)

Anti-Citrullinated Protein Antibodies (ACPA) are specific antibodies produced by the immune system that target proteins modified through a process called citrullination. These antibodies are most commonly associated with rheumatoid arthritis (RA), a chronic inflammatory joint disease. The presence of ACPA helps in diagnosing RA and can indicate a more aggressive form of the disease. Their detection suggests the immune system mistakenly attacks the body's own tissues, contributing to joint inflammation and damage. Understanding ACPA aids in early diagnosis and tailored treatment strategies for affected individuals.