ACMG variant classification system

The ACMG (American College of Medical Genetics and Genomics) variant classification system is a standardized way to determine how changes in a person's genes might affect their health. It categorizes genetic variants into five groups: "pathogenic" (likely harmful), "likely pathogenic," "uncertain significance" (unclear impact), "likely benign," and "benign" (not harmful). This helps doctors and researchers interpret genetic test results accurately, guiding diagnosis, treatment, and counseling by providing a consistent framework for understanding the significance of genetic differences.