ACMG Practice Guidelines

The ACMG Practice Guidelines are recommendations developed by the American College of Medical Genetics and Genomics to assist healthcare providers in interpreting genetic test results. They aim to ensure consistent and accurate classification of genetic variants, helping clinicians understand their potential impact on health. By categorizing variants into groups based on their clinical significance—such as pathogenic, likely pathogenic, uncertain significance, likely benign, or benign—these guidelines support informed decision-making in patient care, risk assessment, and management of genetic disorders.