Aβ (Amyloid Beta) Hypothesis

The Aβ (Amyloid Beta) Hypothesis suggests that the buildup of amyloid beta protein in the brain plays a central role in Alzheimer's disease. Normally, this protein is cleared away, but in Alzheimer's, it accumulates into sticky plaques that damage nerve cells. This buildup triggers inflammation and disrupts communication between brain cells, leading to memory loss and cognitive decline. The hypothesis assumes that targeting amyloid beta formation or removal could slow or prevent the disease’s progression. While widely studied, it's one part of a complex puzzle involving other factors contributing to Alzheimer’s.