8-21 translocation

The 8-21 translocation is a genetic abnormality where parts of chromosome 8 and chromosome 21 swap places. This rearrangement can affect how genes are expressed, and it’s often associated with certain types of leukemia, specifically acute myeloid leukemia (AML). This translocation creates a fusion gene that contributes to abnormal cell growth. Detecting this abnormality helps doctors diagnose and determine the best treatment strategy for affected individuals. In essence, it’s a specific change in the genetic blueprint that impacts blood cell development.