2-hydroxyglutarate

2-Hydroxyglutarate (2-HG) is a chemical compound that can accumulate in the body, often as a result of genetic mutations or certain diseases like cancer. It resembles a normal molecule involved in cell metabolism but can interfere with the cell’s normal functions when present in excess. High levels of 2-HG are linked to altered cell behavior and can contribute to the development and progression of some tumors. Scientists study 2-HG to better understand these diseases and develop targeted treatments.